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VITAMINA C: L’ACIDO ASCORBICO O CALCIO ASCORBATO

La vitamina C è una delle sostanze più conosciute efficaci e sopratutto senza nessuna controindicazione. In più, è un potente antiossidante contro i radicali liberi; va ribadito che la vitamina C funziona  bene in acqua sia come intracellulare che extracellulare. Inoltre, la vitamina C incrementa l’azione di una vitamina antiossidante, la vitamina E, che ha funzioni liposolubili cioé che si scoglie nei grassi.

super-c-1000

E’ importante sapere che gli animali sono capaci di produrre vitamina C in maniera naturale, mentre che noi esseri umani abbiamo perso questa capacità, proporzionare questa vitamina al nostro corpo è fondamentale, e la possiamo ottenere mediante alimenti come la frutta fresca e soprattutto le verdure.

Dall’Antichità fino ai primi anni del XIX secolo, i marinai sviluppavano una malattia chiamata scorbuto. Lo scorbuto causava contusioni, ferite di difficile guarigione, sanguinamento delle gengive e debolezza generale. Questa malattia era dovuta alla carenza di vitamina C e il trattamento dello scorbuto consisteva nel  semplice consumo d’agrumi.

Qualche secolo dopo, Albert Szent-Gyorgyi, un fisiologo ungherese, ha isolato il principio attivo, definendola come anti-scorbuto, e successivamente come acido ascorbico o vitamina C.  È importante sapere che una delle multifunzione della vitamina C è quella di aumentare la produzione di collageno nel corpo. Il collageno è molto importante per i nostri tessuti connettivi quali i tendini ed le cartilagini. Oltre a queste funzioni, la vitamina C  può anche offrire altri vantaggi:

1. Stress

Una meta-analisi ha rivelato che la vitamina C è utile per le persone che presentano un sistema immunitario indebolito a causa dello stress. Inoltre, i fumatori, le persone alcoliche e persone con obesità (situazioni di stress organico) hanno  livelli  di vitamina C molto bassi. Quest’ultimo è importante perché la vitamina C è una vitamina molto sensibile.

2. Influenza

La vitamina C, o più correttamente Acido Ascorbico, è una molecola idrosolubile che svolge numerose funzioni essenziali: tra queste pare che sia stata riconosciuta la sua capacità di prevenire e ridurre i sintomi del raffreddore comune; l’argomento è comunque tutt’ora controverso.

3. Circolatorio.

Le persone che hanno una maggiore concentrazione di vitamina C nel sangue hanno un rischio minore (42 %) di subire un ictus (CVA) che quelli con un livello più basso. Un’altro studio ha rivelato che 500 mg. di vitamina C tutti giorni abbassano la pressione sanguigna in un 10 %.

4. L’invecchiamento della pelle.

Prima, La vitamina C ha funzioni a livello intracellulare e anche a livello extracellulare. Infatti, uno studio pubblicato sull’American Journal of Clinical Nutrition ha esaminato la relazione tra l’assunzione di nutrienti e l’invecchiamento della pelle in 4.025 donne, in età compresa tra 40-74 anni. E’ stato cosi osservato che le donne che assumevano vitamina C erano meno proclivi ad avere rughe e pelle secca. In somma, loro avevano un migliore aspetto della pelle in generale.

Inoltre, gli studi dimostrano che la vitamina C può avere un effetto sinergico insieme ad altri anti ossidanti e sostanze anti-infiammatori aiutando cosi a combattere il cancro. In diabetici è stato dimostrato che la vitamina C può aiutare a controllare livelli di glucosio nel sangue.

In piu si è visto che le persone con problemi di stomaco trovano interessante l’utilizzazione di vitamina C perché può aiutarli a proteggergli contro l’azione ossidativa causato dal batterio Helicobacter pylori che è la principale causa delle ulcere e gastriti dello stomaco.

La dosi di vitamina C dovrebbe essere superiore alla dose giornaliera raccomandata (RDA), 60mg. La maggior parte degli studi hanno utilizzato 500 mg. al giorno per migliorare la salute.

Qui il problema è che per raggiungere 500 mg. dobbiamo mangiare molta frutta e verdura, nonostante, ci siano molti integratori di vitamina C.

Dobbiamo sapere che alcune persone soffrono d’irritazione a causa della vitamina C (acido ascorbico),  Per loro c’è  una forma di vitamina C che non acida: ad esempio l’ascorbato di calcio, l’ascorbato di potassio, ecc. Così, potreste evitare qualsiasi problema gastrointestinale.

Pedro Encinas

Dietista sportivo e Fisioterapista

Bibliografia:

  • Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, et al. Antioxidant supplemen-tation and lung function in children with asthma exposed to high levels of air pollutants. Am J Respir Crit Care Med 2002 September 1, 166 (5):703-9.
  • Hemila H. Vitamin C and the common cold. Br J Nutr. 1992; 67:3-16.
  • Hemila H. Vitamin C supplementation and common cold symptoms: factors affecting the magnitude of the benefit. Med Hypotheses. 1999; 52:171-178.
  • Hemila H. Vitamin C supplementation and common cold symptoms: factors affecting the magnitude of the benefit. Med Hypotheses. 1999; 52:171-178.
  • Douglas RM, Chalker EB, Treacy B. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2000; CD000980.
  • Douglas R, Hemila H, D’Souza R, et al. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2004; CD000980.
  • Peters EM, Goetzsche JM, Grobbelaar B, et al. Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners. Am J Clin Nutr. 1993; 57:170-174.
  • Hemila H. Vitamin C and common cold incidence: a review of studies with subjects under heavy physical stress. Int J Sports Med. 1996; 17:379-383.
  • Petersen EE, Magnani P. Efficacy and safety of vitamin C vaginal tablets in the treatment of non-specific vaginitis; A randomised, double blind, placebo-controlled study. Eur J Obstet Gynecol Reprod Biol. 2004; 117:70-75.
  • Duffy SJ, Gokce N, Holbrook M, et al. Treatment of hypertension with ascorbic acid. Lancet. 1999; 354:2048.
  • Bast A, Haenen GR, Bruynzeel AM, van d, V. Protection of flavonoids against anthracycline cardiotoxicity: from chemistry to clinical trials. Cardiovasc Toxicology 2007, 7 (2):154-9.
  • bdel-Latif MM, AA Raouf, Sabra K, Kelleher D, Reynolds JV. Vitamin C improves chemosensitization of esophageal cancer cells in vitro. J Chemother. 2005 Oct, 17 (5) :539-49.
  • Chen J, Kang J, Da W, Ou Y. Combination with water soluble antioxidants increases the anticancer activity of quercetin in human leukemia cells. Pharmazie. 2004 Nov, 59 (11) :859-63.
  • Antioxidants Chen J, Wanming D, Zhang D, Liu Q, Kang J. improve water soluble antioxidant and anti-cancer activity of low concentrations of curcumin on human leukemia cells. Pharmazie. 2005 Jan, 60 (1) :57-61.
  • Blanchard J, Tozer TN, Rowland M. Pharmacokinetic perspective on megadoses of ascorbic acid. Am J Clin Nutr. 1997;66:1165-1171.
  • Rossig L, Hoffmann J, Hugel B, et al. Vitamin C inhibits endothelial cell apoptosis in congestive heart failure. Circulation. 2001 Oct 30;104(18):2182-7.Salonen RM, Nyyssonen K, Kaikkonen J, et al. Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study. Circulation. 2003 Feb 25;107(7):947-53.
  • Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, et al. Antioxidant supplemen-tation and lung functions among children with asthma exposed to high levels of air pollutants. Am J Respir Crit Care Med. 2002 Sep 1;166(5):703-9.
  • Guz J, Dziaman T, Szpila A. Do antioxidant vitamins influence carcinogenesis?. Postepy Hig Med Dosw.(Online.). 2007; 61:185-98.
  • Afkhami-Ardekani M, Shojaoddiny-Ardekani A. Effect of vitamin C on blood glu-cose, serum lipids & serum insulin in type 2 diabetes patients. Indian J Med Res. 2007 Nov; 126(5):471-4.
  • Woollard KJ, Loryman CJ, Meredith E, et al. Effects of oral vitamin C on mono-cyte: endothelial cell adhesion in healthy subjects. Biochem Biophys Res Commun. 2002 Jun 28; 294(5):1161-8.
  • Rayment SJ, Shaw J, Woollard KJ, Lunec J, Griffiths HR. Vitamin C supplemen-tation in normal subjects reduces constitutive ICAM-1 expression. Biochem Biophys Res Commun. 2003 Aug 22; 308(2):339-45.
  • Tahir M, Foley B, Pate G, et al. Impact of vitamin E and C supplementation on serum adhesion molecules in chronic degenerative aortic stenosis: a randomi-zed controlled trial. Am Heart J. 2005 Aug;150(2):302-6.
  • Hajjar IM, George V, Sasse EA, Kochar MS. A randomized, double-blind, controlled trial of vitamin C in the management of hypertension and lipids. Am J Ther. 2002 Jul; 9(4):289-93.
  • Haffner SM. Relationship of metabolic risk factors and development of cardiovascular disease and diabetes. Obesity (Silver Spring). 2006 Jun;14 Suppl 3:121S-7S.
  • Johnston CS, Beezhold BL, Mostow B, Swan PD. Plasma vitamin C is inversely related to body mass index and waist circumference but not to plasma adiponectin in nonsmoking adults. J Nutr. 2007 Jul; 137(7):1757-62.
  • Wilkinson IB, Megson IL, MacCallum H, et al. Oral vitamin C reduces arterial stiffness and platelet aggregation in humans. J Cardiovasc Pharmacol. 1999 Nov; 34(5):690-3.
  • Dietrich M, Block G, Benowitz NL, et al. Vitamin C supplementation decreases oxidative stress biomarker f2-isoprostanes in plasma of nonsmokers exposed to environmental tobacco smoke. Nutr Cancer. 2003;45(2):176-84.
  • Majewicz J, Rimbach G, Proteggente AR, et al. Dietary vitamin C down-regulates inflammatory gene expression in apoE4 smokers. Biochem Biophys Res Commun. 2005 Dec 16; 338(2):951-5.
  • Thompson D, Williams C, McGregor SJ, et al. Prolonged vitamin C supplemen-tation and recovery from demanding exercise. Int J Sport Nutr Exerc Metab. 2001 Dec; 11(4):466-81.
  • Thompson D, Williams C, Garcia-Roves P, et al. Post-exercise vitamin C supple-mentation and recovery from demanding exercise. Eur J Appl Physiol. 2003 May;89(3-4):393-400.
  • Murali G, Panneerselvam C. Age-associated oxidative macromolecular damages in rat brain regions: role of glutathione monoester. J Gerontol A Biol Sci Med Sci. 2007 Aug; 62(8):824-30.
  • Yuan Q, Zhu X, Sayre LM. Chemical nature of stochastic generation of protein-based carbonyls: metal-catalyzed oxidation versus modification by products of lipid oxidation. Chem Res Toxicol. 2007 Jan; 20(1):129-39.
  • Goldfarb AH, Patrick SW, Bryer S, You T. Vitamin C supplementation affects oxidative-stress blood markers in response to a 30-minute run at 75% VO2max. Int J Sport Nutr Exerc Metab. 2005 Jun; 15(3):279-90.
  • Bryer SC, Goldfarb AH. Effect of high dose vitamin C supplementation on muscle soreness, damage, function, and oxidative stress to eccentric exercise. Int J Sport Nutr Exerc Metab. 2006 Jun;16(3):270-80.
  • Block G, Jensen C, Dietrich M, et al. Plasma C-reactive protein concentrations in active and passive smokers: influence of antioxidant supplementation. J Am Coll Nutr. 2004 Apr; 23(2):141-7.
  • Moller P, Viscovich M, Lykkesfeldt J, et al. Vitamin C supplementation decreases oxidative DNA damage in mononuclear blood cells of smokers. Eur J Nutr. 2004 Oct; 43(5):267-74.
  • Bruno RS, Leonard SW, Atkinson J, et al. Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation. Free Radic Biol Med. 2006 Feb 15; 40(4):689-97.
  • Young JM, Shand BI, McGregor PM, Scott RS, Frampton CM. Comparative effects of enzogenol and vitamin C supplementation versus vitamin C alone on endothelial function and biochemical markers of oxidative stress and inflamma-tion in chronic smokers. Free Radic Res. 2006 Jan; 40(1):85-94.
  • Stadler N, Eggermann J, Voo S, Kranz A, Waltenberger J. Smoking-induced monocyte dysfunction is reversed by vitamin C supplementation in vivo. Arterioscler Thromb Vasc Biol. 2007 Jan; 27(1):120-6.
  • Sasazuki S, Sasaki S, Tsubono Y, et al. Effect of vitamin C on common cold: randomized controlled trial. Eur J Clin Nutr. 2006 Jan; 60(1):9-17.
  • Van SM, Josling P. Preventing the common cold with a vitamin C supplement: a double-blind, placebo-controlled survey. Adv Ther. 2002 May; 19(3):151-9.
  • Romieu I, Trenga C. Diet and obstructive lung diseases. Epidemiol Rev. 2001; 23(2):268-87.
  • Trenga CA, Koenig JQ, Williams PV. Dietary antioxidants and ozone-induced bronchial hyperresponsiveness in adults with asthma. Arch Environ Health. 2001 May;56(3):242-9.
  • Tecklenburg SL, Mickleborough TD, Fly AD, Bai Y, Stager JM. Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma. Respir Med. 2007 Aug; 101(8):1770-8.
  • Fogarty A, Lewis SA, Scrivener SL, et al. Corticosteroid sparing effects of vitamin C and magnesium in asthma: a randomised trial. Respir Med. 2006 Jan; 100(1):174-9.
  • Bast A, Haenen GR, Bruynzeel AM, Van d, V. Protection by flavonoids against anthracycline cardiotoxicity: from chemistry to clinical trials. Cardiovasc Toxicol. 2007;7(2):154-9.
  • bdel-Latif MM, Raouf AA, Sabra K, Kelleher D, Reynolds JV. Vitamin C enhances chemosensitization of esophageal cancer cells in vitro. J Chemother. 2005 Oct;17(5):539-49.
  • Chen J, Kang J, Da W, Ou Y. Combination with water-soluble antioxidants increases the anticancer activity of quercetin in human leukemia cells. Pharmazie. 2004 Nov; 59(11):859-63.
  • Chen J, Wanming D, Zhang D, Liu Q, Kang J. Water-soluble antioxidants improve the antioxidant and anticancer activity of low concentrations of curcumin in human leukemia cells. Pharmazie. 2005 Jan;60(1):57-61.
  • Correa P, Fontham ET, Bravo JC, et al. Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-helicobacter pylori therapy. J Natl Cancer Inst. 2000 Dec 6;92(23):1881-8.
  • Maramag C, Menon M, Balaji KC, Reddy PG, Laxmanan S. Effect of vitamin C on prostate cancer cells in vitro: effect on cell number, viability, and DNA synthesis. Prostate. 1997 Aug 1;32(3):188-95.
  • Wei DZ, Yang JY, Liu JW, Tong WY. Inhibition of liver cancer cell proliferation and migration by a combination of (-)-epigallocatechin-3-gallate and ascorbic acid. J Chemother. 2003 Dec;15(6):591-5.
  • Paolisso G, Balbi V, Volpe C, et al. Metabolic benefits deriving from chronic vitamin C supplementation in aged non-insulin dependent diabetics. J Am Coll Nutr. 1995 Aug;14(4):387-92.
  • Chuang CH, Sheu BS, Kao AW, et al. Adjuvant effect of vitamin C on omeprazole-amoxicillin-clarithromycin triple therapy for Helicobacter pylori eradication. Hepatogastroenterology. 2007 Jan;54(73):320-4.
  • Sun YQ, Girgensone I, Leanderson P, Petersson F, Borch K. Effects of antioxidant vitamin supplements on Helicobacter pylori-induced gastritis in Mongolian gerbils. Helicobacter. 2005 Feb;10(1):33-42.
  • Waring AJ, Drake IM, Schorah CJ, et al. Ascorbic acid and total vitamin C concentrations in plasma, gastric juice, and gastrointestinal mucosa: effects of gastritis and oral supplementation. Gut. 1996 Feb;38(2):171-6.
  • Available at: http://lpi.oregonstate.edu/infocenter/vitamins/vitaminC/. Acce-ssed January 25, 2008.
  • Available at:

http://pdrhealth.com/search/searchresults.aspx?searchTerm=vitamin+c.Accessed January 25, 2008.

  • Lenton KJ, Sane AT, Therriault H, et al. Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency. Am J Clin Nutr. 2003 Jan;77(1):189-95.
  • Tipoe GL, Leung TM, Hung MW, Fung ML. Green tea polyphenols as an anti-oxidant and anti-inflammatory agent for cardiovascular protection. Cardiovasc Hematol Disord Drug Targets. 2007 Jun;7(2):135-44.
  • Comelli MC, Mengs U, Schneider C, Prosdocimi M. Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy. Integr Cancer Ther. 2007 Jun;6(2):120-9.
  • Nicolls MR, Haskins K, Flores SC. Oxidant stress, immune dysregulation, and vascular function in type I diabetes. Antioxid Redox Signal. 2007 Jul;9(7):879-89.
  • Sureda A, Batle JM, Tauler P, et al. Hypoxia/reoxygenation and vitamin C intake influence NO synthesis and antioxidant defenses of neutrophils. Free Radic Biol Med. 2004 Dec 1;37(11):1744-55.
  • Polidori MC, Mecocci P, Frei B. Plasma vitamin C levels are decreased and correlated with brain damage in patients with intracranial hemorrhage or head trauma. Stroke. 2001 Apr;32(4):898-902.
  • Mallette FA, Ferbeyre G. The DNA damage signaling pathway connects oncogenic stress to cellular senescence. Cell Cycle. 2007 Aug 1;6(15):1831-6.
  • Krohn K, Maier J, Paschke R. Mechanisms of disease: hydrogen peroxide, DNA damage and mutagenesis in the development of thyroid tumors. Nat Clin Pract Endocrinol Metab. 2007 Oct;3(10):713-20.
  • Wintergerst ES, Maggini S, Hornig DH. Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab. 2007;51(4):301-23.
  • Hughes DA. Effects of dietary antioxidants on the immune function of middle-aged adults. Proc Nutr Soc. 1999 Feb;58(1):79-84.
  • El-Taukhy MA, Salama SM, bou-Shousha SA, Ismail SS, Saleh M. Effects of chronic ethanol and vitamin C administration on production of tumor necrosis factor-alpha and interleukin-6 in rats. Egypt J Immunol. 2006;13(1):1-10.

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